Desuppressed Expressionsof MiR-29 targetsdisturb the Leukemeugenesis of MLL-AF9
نویسندگان
چکیده
منابع مشابه
miR-150 blocks MLL-AF9-associated leukemia through oncogene repression.
UNLABELLED The microRNA miR-150, a critical regulator of hematopoiesis, is downregulated in mixed-lineage leukemia (MLL). In this study, miR-150 acts as a potent leukemic tumor suppressor by blocking the oncogenic properties of leukemic cells. By using MLL-AF9-transformed cells, we demonstrate that ectopic expression of miR-150 inhibits blast colony formation, cell growth, and increases apoptos...
متن کاملPolycomb repressive complex 2 is required for MLL-AF9 leukemia.
A growing body of data suggests the importance of epigenetic mechanisms in cancer. Polycomb repressive complex 2 (PRC2) has been implicated in self-renewal and cancer progression, and its components are overexpressed in many cancers. However, its role in cancer development and progression remains unclear. We used conditional alleles for the PRC2 components enhancer of zeste 2 (Ezh2) and embryon...
متن کاملMRI/ MRS on Leukemia Development in MLL-AF9 Transgenic Mice
D. DeRyckere, M. E. Macy, K. M. Hasebroock, L. A. Gardner, P. Jedlicka, E. L. Bradshaw-Pierce, A. L. Merz, L. Gore, and N. J. Serkova Medical Oncology, University of Colorado Health Sci, Aurora, CO, United States, Anesthesiology, University of Colorado Health Sci, Aurora, CO, United States, Pediatrics, University of Colorado Health Sci, Aurora, CO, United States, Pathology, University of Colora...
متن کاملThe leukemogenic fusion gene MLL-AF9 alters microRNA expression pattern and inhibits monoblastic differentiation via miR-511 repression
BACKGROUND In this study we explored the role of microRNAs (miRNAs) as mediators of leukemogenic effects of the fusion gene MLL-AF9, which results from a frequent chromosomal translocation in infant and monoblastic acute myeloid leukemia (AML). METHODS We performed a specific and efficient knockdown of endogenous MLL-AF9 in the human monoblastic AML cell line THP1. RESULTS The knockdown ass...
متن کاملmiR-125b promotes MLL-AF9-driven murine acute myeloid leukemia involving a VEGFA-mediated non-cell-intrinsic mechanism.
The hematopoietic stem cell-enriched miR-125 family microRNAs (miRNAs) are critical regulators of hematopoiesis. Overexpression of miR-125a or miR-125b is frequent in human acute myeloid leukemia (AML), and the overexpression of these miRNAs in mice leads to expansion of hematopoietic stem cells accompanied by perturbed hematopoiesis with mostly myeloproliferative phenotypes. However, whether a...
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ژورنال
عنوان ژورنال: Blood
سال: 2015
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v126.23.1228.1228